As a general rule, the runes don't play a direct part in Animism or Sorcery. Spirits are entities that you control or otherwise bargain with - their strength comes from your status as a spirit society member or a shaman and not from your runes. However, there are exception (frex, folk who possess the Spirit Rune - those folk are natural spirit talkers).
Wizardry is something you know, not something you are. You can be a sadistic murdering monster and have mastered the Grimoire of Xemela far better than the compassionate lifegivers. Again, there are always exceptions to this (frex the LM sorcerers use their Law Rune to master the Torvald Fragments Grimoire).
On the other hand, I'd certainly allow a character to augment their wizardry or their spirit with a personal rune. That way Windy Wahagrim (with a strong connection to the Air Rune) is likely going to have an edge with Air spirits over his compatriots, and Fekesmel the Unruly is particularly feared for his command of the destructive spells in the Book of Return.
Jeff
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